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KMID : 1007520130220030859
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Food Science and Biotechnology
2013 Volume.22 No. 3 p.859 ~ p.864
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Supercritical Fluid Extract from Maca Alleviates Colitis Induced by Dextran Sulfate Sodium in Mice
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Cho Jae-Young
Choi Eun-Hye
Kang Jung-Il
Choi Chang-Sun
Chun Hyang-Sook
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Abstract
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The objective of this study was to investigate the possible protective effects of maca (Lepidium meyenii) extract (MLE) by supercritical fluid extraction on dextran sodium sulfate (DSS)-induced colitis. Experimental colitis was induced by giving male BALB/c mice 3% DSS in drinking water, and MLE (30 mg/kg BW), sulfasalazine (100 mg/kg BW) or vehicle were administered orally. DSS challenge caused significant body weight loss, rectal bleeding, diarrhea, shortened colon length, histological changes, and increased myeloperoxidase (MPO) activity in DSS-treated mice. Oral administration of MLE significantly relieved the symptoms of diarrhea and rectal bleeding, and reduced colonic MPO activity (p<0.05). MLE treatment inhibited expression of several colonic proteins related to inflammatory responses, such as interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and S100 calcium-binding protein A8, whose expressions were increased significantly by DSS treatment. These results suggest that MLE can alleviate DSS-induced colitis in mice by modulating colonic inflammatory mediators.
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KEYWORD
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colitis, dextran sulfate sodium, inflammation, maca extract, supercritical fluid extraction
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